One of the methods used to dispose toxic lipophilics is by degradation of the large compounds into small polar fragments thatcan be eliminated through the urine or bile. Oxidative metabolism of toxic cyclic and polycyclic hydrocarbons is done with the introduction of a hyroxyl group into the ring structure. The excretion of halogenated hydrocarbons is extremely difficult. Their accumulation in the body occurs in both adipose tissue and lipid layers of the skin. They will stay there for the duration of theanimals life time.
The molecular weight of a compound will determine if the compound will be excreted in the urine or feces. Any elimination of a xenobiotic will be done in association with the excretion of another compound that is normally eliminated by the body. Most gaseous and volatile xenobiotics are eliminated through the lungs. The rate of ecretion is based on how soluble the compond is in the blood, the rate of volume of respiration, and the rateof blood flow to the lungs. Asecond method used is the alveolobronchilar transport mechanism. …
