Alzheimer's disease
1) Primary Source - "FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a y-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the y-Secretase Cleavage Complex"
Alzheimer's disease (AD) causes mutations in presenilin-1 (PS1) and presenilin -2 (PS2) that increase the formation of amyloid B-peptides (AB). AB is formed by increasing the cleavage of B-amyloid precursor protein (APP), and the cleavage of APP is performed by y-secretase. So in simpler terms, AB peptides are formed by the cleavage of APP by B- and y- secretase.…
