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ID number:626579
Author:
Evaluation:
Published: 23.11.2018.
Language: Latvian
Level: College/University
Literature: 3 units
References: Not used
Extract

Biotransformācija
Atorvastatīns ar citohroma P450 3A4 starpniecību tiek metabolizēts par orto- un parahidroksilētajiem metabolītiem un dažādiem beta oksidācijas produktiem.
Papildus citiem metabolisma veidiem, šie savienojumi pēc tam tiek metabolizēti caur glikuronidāciju.

Eliminācija
Izdalās ar žulti pēc metabolisma aknās un/vai ārpus tām.
Vidējais plazmas eliminācijas pusperiods ir aptuveni 14 stundas.
Pateicoties aktīvo metabolītu klātbūtnei, HMG-CoA reduktāzi inhibējošās aktivitātes pusperiods ir 20-30 stundas.

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