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ID number:711337
Published: 05.03.2010.
Language: English
Level: College/University
Literature: n/a
References: Not used
Table of contents
Nr. Chapter  Page.
  What is the OCS?   
  Historical challenges   
  Main parts   
  Working principle   

What is the Organ Care System?
The first commercial, portable, warm blood perfusion system that allows a new type of organ transplant.

It is designed to maintain organs in a warm, functioning state outside of the body to optimize their health and allow continuous clinical evaluation.

Historical challenges
Challenge No. 1 - Hemolysis
Novel pulsatile pump, valves, circuit, and cannulae design to reduce shear stress and minimize hemolysis
Challenge No. 2 - Biocompatibility & Inflammation
Biocompatible materials used for all blood contacting surfaces
Leukocyte and platelet depletion
Heparin coating of surface area of the perfusion circuit
Use of TMI solution
Challenge No. 3 - Substrate Depletion
TransMedics’ solution sets designed to supply and maintain steady state of needed substrate to ensure stable metabolic function
Challenge No. 4 - Contamination
Dual barrier chamber design
Access for sampling and antibiotics administration
Challenge No. 5 - Portability
Robust design using lightweight composite materials and custom power and gas sources.…

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